Preparation of sized populations of liposomes

Details Preparation of sized populations of liposomes Preparation of sized populations of liposomes

A - Human Necessities

61

K

167/163, 117/46.

A61K 9/127 (2006.01) B01J 13/02 (2006.01) G01N 33/543 (2006.01)

Patent

CA 1336067

The present invention provides novel methods for generating aqueous liquid encapsulating multi- lamellar lipid vesicles (liposomes) wherein one or more lipids, or lipid conjugates, and an aqueous liquid to be encapsulated, are agitated in a vessel in the presence of spherical contact masses having a mean diameter of less than 3,000 microns, the preferred size range being 50-100 microns in diameter, and resulting in a substan- tially homogeneous population of vesicles having diameters in the range of about 150 to about 3,000 nano- meters. The methods allow for the use of small quanti- ties of marker and lipid, leave no residual solvents, allow for contact only with glass surfaces, and involve no transfer of liposome preparations from lipid film drying vessels to sizing apparatus.

583742

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