Conjugates of leukotrienes with proteins

Details Conjugates of leukotrienes with proteins Conjugates of leukotrienes with proteins

G - Physics

01

N

167/129, 167/139

G01N 33/532 (2006.01) A61K 39/12 (2006.01) G01N 33/88 (2006.01) G01N 33/92 (2006.01)

Patent

CA 1240669

TITLE OF THE INVENTION CONJUGATES OF LEUKOTRIENES WITH PROTEINS ABSTRACT OF THE INVENTION Leukotrienes may be conjugated with various proteins such as Bovine Serum Albumin (BSA) and Hemocyanin from Giant Keyhole Limpets (KLH) using 1,5-difluoro-2,4-dinitrobenzene or 6-N-maleimidohexanoic acid chloride as coupling agents. These conjugates are useful as reagents in a newly developed immunoassay for leukotrienes, as well as having potential utility as chemical immunotherapeutic agents in the treatment of various allergic and chronic inflammatory diseases of the skin, lung, and airways, including asthma, allergic rhinitis, rheumatoid arthritis, and skin diseases such as psoriasis and eczema.

466742

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