Biocompatible poly-(ether-urethane-urea) and process for its...

C - Chemistry – Metallurgy – 08 – G

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C08G 18/83 (2006.01) A61L 27/18 (2006.01) C08G 18/10 (2006.01)

Patent

CA 1209158

BIOCOMPATIBLE POLY-(ETHER-URETHANE-UREA) AND PROCESS FOR ITS PREPARATION Abstract An improved biocompatible and hemocompatible segmented poly-(ether-urethane-urea) is prepared by a process which comprises condensing an alkylene poly- ether diol of molecular weight of 500 to 6000 with substantially two equivalents of an aryl, aralkyl, or alkyl diisocyanate of 6 to 20 carbon atoms; condensing the thus-formed .alpha.,.OMEGA.-diisocyanato poly-(ether-urethane) with a substantially equivalent proportion of a primary alkyl diamine of 2 to 6 carbon atoms until a degree of condensation of about 5 to 20 is achieved; condensing the resulting poly-(ether-urethane-urea) with a primary alkyl amine or diamine of up to 6 carbon atoms in an amount substantially equivalent to the free isocyanate content of the poly-(ether-urethane-urea); and condensing the amine-treated poly-(ether-urethane-urea) with an amine- reacting agent in an amount substantially equivalent to the free amine content of the amine-treated poly-(ether- urethane-urea). The polymer is especially suitable for fabricating replacements for damaged cardiovascular and urinary tract vessels.

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