Improved t-pa lacking the first kringle domain

Details Improved t-pa lacking the first kringle domain Improved t-pa lacking the first kringle domain

C - Chemistry, Metallurgy

12

N

530/13, 195/1.23

C12N 9/72 (2006.01) A61K 38/49 (2006.01) C12N 15/12 (2006.01) C12N 15/66 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341445

The present invention relates to a novel improved tissue plasminogen activator (improved t-PA) having a prolonged biological half life and increased stability to heat and acids which can expect an inhibitory effect against inflammation around the thrombus-formed region. The present invention further includes deoxyribonucleic acid (UNA) coding for the said improved t-PA, a recombinant expression vector containing DNA encoding the improved t-PA, host cells transformed by said expression vector, a process for production of the improved t-PA, a drug composition comprising the improved t-PA and its use for treatment of thrombotic disease.

597910

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