Dihydropyridines

Details Dihydropyridines Dihydropyridines

C - Chemistry, Metallurgy

07

D

260/246, 260/251

C07D 401/12 (2006.01) C07D 211/90 (2006.01) C07D 295/088 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 1205470

ABSTRACT OF THE DISCLOSURE Novel 1,4-Dihydropyridine derivatives of the formula:- Image --- (I) their pharmaceutically acceptable acid addition salts and their process of preparation; where R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)- or -CH2C(CH3)2-; R3 is hydrogen or a group selected from:- (a) Image where R4 is H, C1-C4 alkyl, C3-C6 cycloalkyl, -COO(C1-C4 alkyl), -CH2COO(C1-C4 alkyl), aryl, -SO2.aryl, or heteroaryl, and X is O or S; (b) Image (C1-C4 alkyl)2; (C) Image where R5 is l-pyrrolidinyl, -NH2, -NH(C1-C4 alkyl), -N(C1-C4 alkyl)2, or -NH(CH2)2N(C1-C4 alkyl)2; (d) Image (C1-C4 alkyl) where R6 is C1-C4 alkyl or aryl; (e) Image where R7 is -CONH(C1-C4 alkyl) or -COO(C1-C4 alkyl); (f) Image (g) Image where R8 is -CN, -SO2(C1-C4 alkyl) or -SO2 aryl; (h) -CH2CO.R9 where R9 is -NH2, -NH(C1-C4 alkyl), -NH.aryl or C1-C4 alkoxy; (i) -SO2.R10 where R10 is -NH2,-N(C1-C4 alkyl)2 or C1-C4 alkyl; and (j) -CO.R11 where R11 is H, halomethyl, -COO(C1-C4 alkyl), -CH2O(C1- C4 alkyl), -CH2CO(C1-C4 alkyl), C1-C4 alkyl, C1-C4 alkoxy, aryl, heteroaryl, morpholino or 5-oxo-pyrrolidin-2-yl, the novel compounds having utility as anti-ischaemic and antihypertensive agents.

435935

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