Preparation of electrolyte solutions and containers

Details Preparation of electrolyte solutions and containers Preparation of electrolyte solutions and containers

A - Human Necessities

61

K

210/47, 128/80

A61K 33/00 (2006.01) A61K 31/22 (2006.01)

Patent

CA 1285528

ABSTRACT OF THE DISCLOSURE Methods are provided for preparing just before administration unit doses of therapeutic solutions which contain redox active unstable and/or diffusable metabolites such as a ketoacid, a sulfhydryl-containing amino acid, or carbon dioxide. The method involves preparing and storing an aqueous solution of stable components which may or may not contain carbon dioxide. A dry powder comprised of unstable components is also prepared and stored separately. These separate component compositions are packaged in, for example, individual chambers of a common sealed container which is so constructed as to permit the opening, by externally applied manual means or the like, of a passageway between such chambers at the time when usage is contemplated. Thus, a fresh solution in desired full dosage form is preparable just before administration. Improved container structures for practice of this method are also provided.

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