Non-antibacterial tetracycline compositions possessing...

A - Human Necessities – 61 – K

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167/268, 99/28

A61K 31/65 (2006.01)

Patent

CA 1297410

ABSTRACT OF THE DISCLOSURE Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti- collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are. useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.

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