23-deoxy-27-halo(chloro or bromo) derivatives of ll-f28249...

Details 23-deoxy-27-halo(chloro or bromo) derivatives of ll-f28249... 23-deoxy-27-halo(chloro or bromo) derivatives of ll-f28249...

C - Chemistry, Metallurgy

07

D

167/202, 260/233

C07D 493/22 (2006.01) A01N 43/90 (2006.01) A61K 31/70 (2006.01) C07H 19/01 (2006.01) C12P 17/18 (2006.01)

Patent

CA 1291128

23-DEOXY-27-HALO(CHLORO OR BROMO) DERIVATIVES OF LL-F28249 COMPOUNDS ABSTRACT The present invention relates to novel derivatives of LL-F28249 compounds. These LL-F28249 compounds preferably are derived via a controlled microbiological fermentation of Streptomyces cyaneogriseus subspecies noncyanogenus having deposit accession number NRRL 15773. The 23-deoxy-27- halo(chloro or bromo) derivatives have the 23-hydroxy group of the LL-F28249 compounds replaced by hydrogen and a halogen such as chlorine or bromine in the 27-position with the double bond shifted to the 26,26'- position. The novel derivatives of the present inven- tion possess activity as anthelmintic, ectoparasitic, insecticidal, acaricidal and nematicidal agents and are useful in areas of human and animal health and in agricultural crops. Compositions containing the present compounds also are presented herein.

560566

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