Certain ring-fused pyrazolo ¬3,4-d|-pyridin-3-one derivatives

Details Certain ring-fused pyrazolo ¬3,4-d|-pyridin-3-one derivatives Certain ring-fused pyrazolo ¬3,4-d|-pyridin-3-one derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/262

C07D 471/04 (2006.01) A61K 31/395 (2006.01) C07D 207/22 (2006.01) C07D 215/54 (2006.01) C07D 215/56 (2006.01) C07D 221/04 (2006.01) C07D 401/12 (2006.01) C07D 471/14 (2006.01) C07D 491/147 (2006.01) C07D 493/04 (2006.01) C07D 493/14 (2006.01) C07D 495/04 (2006.01) C07D 495/14 (2006.01)

Patent

CA 1263651

4-1500/+/CGC 1089 Certain ring-fused pyrazolo[3,4-d]-pyridin -3-one derivatives Abstract of Disclosure Compounds of the formula IA or IB Image (IA) or Image (IB) wherein A represents an optionally substituted saturated divalent grouping which together with the two carbon atoms to which it is attached represents a fused 5-, 6- or 7-membered carbocyclic or heterocyclic ring selected from optionally substituted fused cyclo- penteno, cyclohexeno, cyclohepteno, dihydrothieno, dihydrothiopyrano, tetrahydrothiepino, dihydrofuro, dihydropyrano, tetrahydrooxepino, dihydropyrrolo, tetrahydropyrido and tetrahydroazepino; R1 represents lower alkyl, phenyl, or phenyl mono- or disubstituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl; or R1 represents an aromatic heterocyclic radical selected from e.g. optionally substituted pyridyl, quinolyl, isoquinolyl, pyrimidyl and thiazolyl; R2, R3, R3 are hydro- gen or lower alkyl; and pharmaceutically acceptable salts; are useful as benzodiazepine receptor modulators for the treatment of nervous system disorders. Pharmaceutical compositions, methods of preparation and certain intermediates useful as benzodiazepine receptor modulators are also disclosed.

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