C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/277
C07D 403/12 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 213/82 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1317296
ABSTRACT OF DISCLOSURE A pharmaceutical composition as a cardioprotective agent or as a therapeutic agent for ischemic disease comprising a compound of the formula: Image wherein R1 is lower alkyl substituted with a heterocyclic group; carbamoyl substituted with heterocyclic(lower)alkyl or with lower alkylamino(lower)alkyl; N-containing heterocycliccarbonyl optionally substituted with lower alkyl; or ureido substituted with lower alkylamino(lower)alkyl; and R2 is phenyl substituted with nitro, and X is =N- or Image , in which R3 is lower alkyl; or R2 is lower alkyl, and X is Image , in which R3 is phenyl substituted with nitro; or its salt, as an active ingredient, in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient, and a process for the preparation of some of said compound or their salts.
579295
Esumi Kimio
Kuno Atsushi
Maeda Kazuhiro
Sakai Hiroyoshi
Sakamoto Yoshie
Esumi Kimio
Fujisawa Pharmaceutical Co. Ltd.
Kuno Atsushi
Maeda Kazuhiro
Sakai Hiroyoshi
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