Insulin derivatives, the use thereof, and a pharmaceutical...

Details Insulin derivatives, the use thereof, and a pharmaceutical... Insulin derivatives, the use thereof, and a pharmaceutical...

C - Chemistry, Metallurgy

07

K

530/7.4, 167/103

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339044

New insulin derivatives, the use thereof, and a pharmaceutical composition containing them New insulin derivatives of the formula II with an iso- electric point between 5 and 8.5, with improved stability in weakly acid aqueous medium and with a special action profile, and the physiologically tolerated salts of these insulin derivatives, for the treatment of diabetes mellitus; formula II is: Image (II) in which R1 denotes H or H-Phe, R2 denotes a genetically encodable L-amino acid which contains no amide group, R30 represents the residue of a neutral genetically encodable L-amino acid, R31 represents a physiologically acceptable organic group which is basic in nature and has up to 50 carbon atoms, in whose structure 0 to 3 .alpha.-amino acids are involved and whose terminal carboxyl group which is present where appropriate can be free, in the form of an ester functionality, an amide func- tionality, a lactone or reduced to CH2OH, and X represents a genetically encodable L-amino acid.

614539

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