3-amino-3,4,6-trideoxyglycals, processes for preparation...

Details 3-amino-3,4,6-trideoxyglycals, processes for preparation... 3-amino-3,4,6-trideoxyglycals, processes for preparation...

C - Chemistry, Metallurgy

07

D

260/358.5, 260/3

C07D 309/28 (2006.01) C07D 307/14 (2006.01) C07D 309/30 (2006.01) C07D 413/04 (2006.01) C07H 15/252 (2006.01)

Patent

CA 1270827

ABSTRACT OF THE DISCLOSURE Processes for preparing new 3-amino-3,4,6- trideoxyglycals 14 and 15, and use of these new compounds for preparing anthracyclines, are described. Image 14 15 The new glycals, of the general Formulae 14 and 15 are prepared by treating glycals of Formula 10 and 11 Image 11 with a mixture of sodium hydride and carbon disulfide, and then with methyl iodide to obtain (S-methyl) dithiocarbonates of general Formula 12 and 13 Image 12 13 the (S-methyl) dithiocarbonate groups of which are eliminated by reduction with tributyltin hydride in the presence of azobis (isobutyronitrile). The glycals of the Formulae 14 and 15 are used to prepare anthracyclines which can be used to prepare medicaments.

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