C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/179, 260/251
C07D 213/46 (2006.01) C07C 45/63 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 49/747 (2006.01) C07C 49/755 (2006.01) C07C 59/68 (2006.01) C07C 225/20 (2006.01) C07D 213/30 (2006.01) C07D 215/14 (2006.01) C07D 215/20 (2006.01) C07D 215/233 (2006.01) C07D 215/38 (2006.01) C07D 241/52 (2006.01) C07D 311/22 (2006.01) C07D 313/08 (2006.01) C07D 405/12 (2006.01)
Patent
CA 1335452
Disclosed are substituted tetralins, chromans and related compounds of the formula: Image (I) [wherein n is 0 or 1; X is CH2, O, S, SO, SO2, NH or N(C1-C4)alkyl; X1 is CH2, O, S, SO or SO2; Y and Y1 together form CO or Y is H and Y1 is OH or acyloxy; Z is CH2, CHCH3, CH2CH2 or CH2CH2CH2; Z1 is CH or N; R is pyridyl, quinolyl, isoquinolyl, pyridazinyl, cinnolyl, phthalazinyl, pyrimidinyl, quinazolyl, pyrazinyl, quinoxalinyl, indolizinyl, oxazolyl; benzoxazolyl, isoxazolyl, benzoisoxazolyl, thiazolyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, imidazolyl, benzimidazolyl, pyrazolyl or indazolyl; and R1 is alkyl, cycloalkyl, bicycloalkyl, cycloalkylalkyl or bicycloalkylalkyl] which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions comprising the compounds; and intermediates useful in the synthesis of the compounds.
580361
Eggler James Frederick
Marfat Anthony
Melvin Lawrence Sherman Jr.
Limited Pfizer
Smart & Biggar
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