C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/313, 260/266
C07D 249/08 (2006.01) A01N 43/653 (2006.01) C07C 45/46 (2006.01) C07D 401/00 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1193253
Abstract Triazole human, plant and seed antifungal agents of the formula:- Image ---(I) where R is phenyl optionally substituted by 1 to 3 substituents each independently selected from F. C1, Br,I, CF3, C1-CL alkyl and C1-C4 alkoxy, or R is a 5-chloropyrid-2-yl group; R1 is -CN, -CSNH2, or -CONR2R3 where either (a) R2 is H or Cl-C, alkyl, and R3 is H, C1-C6 alkyl, benzyl, phenethyl, phenyl, -CH2CF3, adamantyl, pyridylmethyl, C3-C7 cycloalkyl, carbamoylmethyl, (C2-C4 alkenyl)methyl, 2-hydroxyethyl, 2-(dimethylamino)ethyl, 2-(methylshio)ethyl, 2-(methylsulphinyl)ethyl, 2-(methylsulphonyl)ethyl or 2-phenoxyethyl; said benzyl, phenethyl, phenyl and phenoxy group being optionally ring-substituted by 1 or 2 substituents each independently selected from C1-C4 alkyl, C1-C4 alkoxy, F, C1, Br, I and CF3, or (b) R2 and R3 taken together with the nitrogen atom to which they are attached represent a group of the formula:- Image where R4 is H, C1-C4 alkyl, C2-C4 alkanoyl or (C1-C4 alkoxy)carbonyl; R5 is H or CH3; and R6 is H or CH3; and their pharmaceutically and agriculturally acceptable salts. The compounds are useful as human and agricultural fungicides.
437742
Gymer Geoffrey E.
Richardson Kenneth
Pfizer Corporation
Smart & Biggar
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