Process for the preparation of 3,4-di-isobutyryloxy-n-...

Details Process for the preparation of 3,4-di-isobutyryloxy-n-... Process for the preparation of 3,4-di-isobutyryloxy-n-...

C - Chemistry, Metallurgy

07

C

260/489.7

C07C 93/26 (1985.01)

Patent

CA 1236848

ABSTRACT OF THE DISCLOSURE A process is provided herein for the preparation of N- benzyl-N-methyl-3,4-di-isobutyryloxyphenethylamine of the Formula (IV) Image (IV) or its acid addition salt. The process involves esterifying N- benzyl-N-methyl-3,4-di-hydroxy-phenethylamine with isobutyryl chloride and an organic base in an organic solvent. This compound (IV) is an intermediate for the preparation of the therapeutically active compound, 3,4-di-isobutyryloxy-N-methyl- phenethyl-amine (I) Image (I) or its acid-addition salts. Compound (I), also known as ibopamine, is a well-known cardiac medicine, which is used especially in heart and kidney insufficiency.

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