Process for the preparation of thioethers

Details Process for the preparation of thioethers Process for the preparation of thioethers

C - Chemistry, Metallurgy

07

D

260/308, 260/559

C07D 285/12 (2006.01) C07D 233/84 (2006.01) C07D 257/04 (2006.01) C07D 285/125 (2006.01) C07D 311/50 (2006.01) C07F 7/08 (2006.01)

Patent

CA 1195688

Abstract Process for the preparation of thioethers by reacting a silylated thiol of the general formula: R - S - SiR1R2R3 I wherein R represents an organic group and R1, R2 and R3 are the same or different and each represents an alkyl group having 1 to 4 carbon atoms, with an or- ganic halide, sulphate or sulphonate in the presence of hexamethylphosphoric triamide as a solvent or co- solvent. The process is carried out under neutral conditions in aprotic solvents at a temperature be- tween 0° and 150°C. The thioethers are useful as intermediates or as sulphur-containing drugs such as cephalosporin drugs.

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