C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/87
C12P 19/00 (2006.01) C07H 15/252 (2006.01)
Patent
CA 1247028
- 1 - Abstract of the disclosure: The present application relates to a microbio- logical process for the preparation of compounds of the formula I Image I in which R denotes hydrogen or hydroxyl and R1 and R2 are identical or different and represent sugar combina- tions of the following composition: - Roa-dF-CinA - Roa-dF-Acu - Roa-dF=CinB - Roa-Rod-CinA or - Roa-Rod-Acu or R2 has the abovementioned meanings and R1 represents sugar combinations of the following composition: - Roa-dF-Rod - Roa-dF-CinB - Roa-dF-Acu - Roa-Rod-Acu - Roa-dF-CinA - Roa-Rod-Rod or - Roa-Rod-CinA in which Roa denotes rhodosamine; dF denotes deoxyfucose; Rod denotes rhodinose; Acu denotes aculose; CinA denotes cinerulose A and CinB denotes cinerulose B, and dF = CinB means that the two sugar units deoxyfucose and cinerulose B are linked by an extra ether bridge, in addition to the usual glycosidic bond, which comprises reacting a compound -2- of the formula II Image II in which R denotes hydrogen or hydroxyl and R3 and R4 are identical or different and represent sugar combinations of the following composition: -Roa-dF-Rod -Roa-Rod-Rod -Roa-dF-CinA or -Roa-Rod-CinA or only R3 or only R4 has the meanings given and the other substituent in each case denotes -Roa-dF-Rod -Roa-dF=CinB -Roa-dF-Acu -Roa-Rod-Acu -Roa-dF-CinA -Roa-Rod-Rod or -Roa-Rod-CinA with a specific oxidoreductase, isolating the resulting compound from the reaction medium by extraction in a manner which is known per se and purifying the product.
479936
Aretz Werner
Berscheid Hans G.
Fehlhaber Hans-Wolfram
Huber Gerhard
Kraemer Hans P.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
LandOfFree
Microbiological process for the preparation of anthracycline... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microbiological process for the preparation of anthracycline..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microbiological process for the preparation of anthracycline... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1226116