C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/45, 167/103.
C07K 14/545 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1322713
A B S T R A C T This invention relates to methods for modulating the effects of TNF and IL-1, both the deleterious and the therapeutical effect of these cytokines. In case of deleterious effects, the invention provides methods for modulating the deleterious effect of TNF and/or IL-1 in mammals, by administering to a mammal sub-deleterious amounts of TNF and/or IL-1. The TNF and/or IL-1 to be modulated may be endogenous, i.e. generated in the organism in severe cases in amounts deleterious to the organism, or exogenously administered to a patient in amounts which are potentially deleterious. The compositions of the invention comprise effective amounts of TNF and/or IL-1 with at least one pharmaceutically acceptable carrier. The invention also relates to methods for monitoring the modulation of the TNF effect in patients treated with TNF and/or IL-1.
546472
Holtmann Helmut
Wallach David
Borden Ladner Gervais Llp
Yeda Research And Development Co. Ltd.
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