Drug-monoclonal antibody conjugates

Details Drug-monoclonal antibody conjugates Drug-monoclonal antibody conjugates

A - Human Necessities

61

K

167/139, 195/1.1

A61K 47/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1303524

LEJ/lc CT-1906 DRUG-MONOCLONAL ANTIBODY CONJUGATES ABSTRACT There is disclosed a drug-monoclonal antibody conjugate wherein the antibody is linked to a antitumor drug using disulfide benzyl carbamate or carbonate as the linker. Also disclosed is a method of delivering an active antitumor drug to the site of tumor cells in a mammal by administering the drug-monoclonal antibody conjugate.

582744

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