A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/258
A61K 31/195 (2006.01) A61K 31/19 (2006.01) A61K 31/405 (2006.01)
Patent
CA 1314232
ABSTRACT The invention relates to a composition for thera- peutic, especially postoperative and posttraumatic, parenteral nutritional support treatment, which compo- sition is based on a conventional amino acid mixture, the composition being characterised in that it also includes L-glutamine and/or alpha-ketoglutarate and optionally L-asparagine, the components of the composi- tion, expressed in g dry component/l aqueous solution, being: glycine (1-12), aspartate (1-10), glutamate (2-12), alanine (2-20), arginine (2-14), cysteine/ cystine (0.4-2.0), histidine (2-8), isoleucine (2-8), leucine (2-8), lysine (2-12), methionine (1-6), phenyl- alanine (4-10), proline (4-lO), serine (2-10), threonine (2-8), tryptophan (1-3), tyrosine (0.2-1), valine (2-8), and additionally 5-30 g/l L-glutamine and/or 5-25 g/l alpha-ketoglutarate, and optionally 0.5-10 g/l L-asparagine and/or acetoacetate, or salts or esters thereof. The invention also relates to the use of L-glutamine and/or its derivative alpha-ketoglutarate, and optional- ly L-asparagine and/or its derivative acetoacetate for the preparation of a composition intended for therapeutic, especially postoperative and posttraumic, parenteral nutritional support treatment, which use is characterised in that L-glutamine and/or alpha-keto- glutarate and optionally L-asparagine and/or acetoace- tate, dissolved in water and sterile-filtered, are added in cold-stored and freeze-dried form or other sterile powder form to a commercial amino acid nutrient solution immediately before the therapeutic treatment.
581559
Ab Erik Vinnars
Fetherstonhaugh & Co.
LandOfFree
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