Bronchodilatory azepino [1,2-a] pyrimideine derivatives and...

Details Bronchodilatory azepino [1,2-a] pyrimideine derivatives and... Bronchodilatory azepino [1,2-a] pyrimideine derivatives and...

C - Chemistry, Metallurgy

07

D

260/241.1

C07D 487/04 (2006.01)

Patent

CA 1217185

ABSTRACT OF THE DISCLOSURE The invention relates to new azepino[1,2-a]pyrimidine derivatives - of the general formula Image I wherein p = 1, 2 - and acid addition salts thereof which can be prepared by a/ reacting a compound of the formula Image II with a compound of the general formula Image III wherein p is as defined above and R7 is alkoxycarbonyl containing 2 to 5 carbon atoms or carboxamido or b/ reacting a compound of the general formula Image IV wherein R8 is alkyl containing 1 to 4 carbon atoms with - 2 - a compound of the general formula Image V wherein R7 is as defined above - and if desired converting a compound of the general formula I to acid addition salt thereof or setting it free from the salt thereof. The new compounds show bronchodilatory activity.

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