Phenoxypropanolamines

Details Phenoxypropanolamines Phenoxypropanolamines

C - Chemistry, Metallurgy

07

C

167/179, 260/267

C07C 229/38 (2006.01) C07D 295/092 (2006.01) C07D 333/20 (2006.01) C07D 333/24 (2006.01) C07D 333/38 (2006.01)

Patent

CA 1262729

Abstract The tertiary and secondary amines of the formulae Image I and Image V-? wherein n signifies 1 or 2, R signifies hydrogen, lower-alkanoyl or phenyl-lower-alkanoyl, X1 signifies phenoxymethyl optionally mono-fluorinated or mono-chlorinated in the ortho-position, x2 signifies lower-alkyl, phenoxymethyl optionally mono-fluorinated or mono-chlorinated in the ortho-position or phenyl optionally monosubstituted by fluorine, chlorine, trifluoromethyl or lower-alkoxy, Y signifies hydrogen or methyl, and Z signifies a phenyl or thienyl residue substituted in a defined manner, and the physiologically compatible salts thereof have cat- abolic activity and can be used for the treatment of obes- ity and diabetes mellitus or for the treatment of condi- tions which are associated with an increased protein breakdown, or as feed additives for fattening animals. They are manufactured starting from corresponding primary amines.

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