C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/210, 260/239
C07D 471/04 (2006.01) A61K 31/55 (2006.01) C07D 243/38 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 1320197
Abstract There are descried new compounds of formula (I) Image (wherein B represents any one of the groups Image (S) (T) (U)'(V) (W); I D represents any one of the groups Image (i) (ii) (iii) Image and Image (iv) (v); X1 and X2 each represents a =CH- group or, if B represents a group S, U or W, either or both of X1 and X2 may also represent a nitrogen atom; A1 represents a straight-chained or branched saturated C2-7 alkylene group; A2 represents a straight-chained or branched saturated C1-5 alkylene group or, if in the 3-position relative to the nitrogen of the saturated heterocyclic ring, A2 may also represent a single bond; Z represent a single bond, or an oxygen or sulphur atom, or a methylene or 1,2-ethylene group R represents a hydrogen atom or a methyl group; R1 represents a branched or unbranched C1-4 alkyl group, and R2 represents a branched or unbranched C1-7 alkyl group optionally substituted by a hydroxy group at its second to seventh carbon atoms, or a cyclo- C3-7-alkyl or cyclo-C3-7-alkylmethyl group, optionally substituted on the cycloalkyl ring by a hydroxy group, or R1 and R2, together with the nitrogen atom between them, form a 4- to 7-membered saturated, monocyclic, heterocyclic ring optionally including in the ring an oxygen atom or Image group; R3 represents a C1-4 alkyl group or a chlorine or hydrogen atom R4 represents a hydrogen atom or a methyl group; R5 and R6 each represents a hydrogen, fluorine, chlorine or bromine atom or a C1-4 alkyl group; R7 represents a hydrogen or chlorine atom or a methyl group; R8 represents a hydrogen atom or a C1-4 alkyl group; R9 represents a hydrogen or halogen atom or a C1-4 alkyl group; R10 represents a hydrogen atom or a methyl group; and R12 represents a branched or unbranched C1-6 alkyl group; with the proviso that if B represents the group T and R7 represents a hydrogen atom, then R3 represents other than a chlorine atom and Z represents other than a sulphur atom), and stereoisomers and salts thereof. The compounds and their salts may be used as vagal pacemakers for the treatment of bradycardia and bradyarrhythmia.
554792
de Jonge Adriaan
Eberlein Wolfgang
Engel Wolfhard
Mayer Norbert
Mihm Gerhard
Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung
Fetherstonhaugh & Co.
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