C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.18, 195/1.
C12N 15/00 (2006.01)
Patent
CA 1218949
THE USE OF EUCARYOTIC PROMOTER SEQUENCES IN THE PRODUCTION OF PROTEINACEOUS MATERIALS ABSTRACT OF THE DISCLOSURE This invention concerns the use of inducible promoter sequences in the production of elevated amounts of pro- teinaceous materials by transformed eucaryotic cells. Eucaryotic cells which have been cotransformed with DNA which includes a gene coding for a desired proteinaceous material such as insulin, human or bovine growth hormone, or an antibody and an inducible promoter sequence and with DNA coding for a selectable phenotype will, in the pres- ence of an inducing agent for the promoter, produce ele- vated quantities of the desired protein. This approach can be used in combination with gene amplification tech- niques to produce particularly high amounts of desired proteins. This invention also provides methods for the therapeutic treatment of genetically defective eucaryotic cells and of persons suffering from genetically-based diseases or ill- nesses such as sickle cell anemia.
436037
Ridout & Maybee Llp
The Trustees Of Columbia University
LandOfFree
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