1,5-benzothiazepine derivatives and production thereof

Details 1,5-benzothiazepine derivatives and production thereof 1,5-benzothiazepine derivatives and production thereof

C - Chemistry, Metallurgy

07

D

260/238.6

C07D 281/10 (2006.01) C07D 417/06 (2006.01)

Patent

CA 1225989

Abstract of the disclosure: Novel 1,5-benzothiazepine derivatives having formula; Image (wherein R1, R2 and R3 each denotes hydrogen, a halogen, lower alkyl group, a lower alkoxy group or a hydroxy group; R4 denotes a lower alkyl group, an allyl group, a lower alkoxy- alkyl group, a lower alkyl group substituted with a hydroxy group or a halogen, a lower alkylaminoalkyl group or a morpho- lino lower alkyl group; X denotes a halogen or hydrogen) are produced from corresponding 1,4-benzothiazine by a ring expansion reaction with trimethylhalosilane, hydrogen peroxide and water. The derivatives have analgesic, antipyretic and antiarrythmic activities.

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