Dioxolenylmethyl ester prodrugs of phosphinic acid ace...

Details Dioxolenylmethyl ester prodrugs of phosphinic acid ace... Dioxolenylmethyl ester prodrugs of phosphinic acid ace...

Category

C - Chemistry, Metallurgy

Subcategory

07

Subsubcategory

F

CPC

167/233, 260/386

IPC codes

C07F 9/6561 (2006.01) C07F 9/572 (2006.01)

Type

Patent

Patent number

CA 1243680

Description

HA276 Abstract Dioxolenylmethyl Ester Prodrugs Of Phosphinic Acid ACE Inhibitors Angiotensin converted enzyme inhibitor activity is exhibited by compounds having the formula Image and salts thereof wherein R1 is hydrogen, aryl, or heteroaryl: R2 is hydrogen, amino, alkanoylamino, arylcarbonylamino, or heteroarylcarbonylamino; R3 is hydrogen, alkyl, or aminoalkyl; R4 and R5 are the same or different and each is hydrogen, alkyl, halogen, aryl, arylalkyl, hydroxy, alkoxy, alkylthio, aryloxy, arylthio, or cycloalkyl, or R4 and R5 taken together are oxo, ethylenedithio or propylenedithio; one of R6 and R7 is Image and the other is hydrogen, alkyl or arylalkyl; HA276 R8 is hydrogen, alkl or aryl; R9 is hydrogen or alkyl, n is 0 or an integer of 1 to 8; m is 0 or 1; and A is -(CH2)p- wherein p is 0 or 1, -NH-, or -O-.

Application Number

448317

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