C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/246, 260/518
C07C 55/00 (2006.01) C07C 55/02 (2006.01) C07C 55/32 (2006.01) C07C 69/34 (2006.01)
Patent
CA 1260952
ABSTRACT A novel class of compounds has been found to be effective in blocking cholesterol and neutral lipid synthesis in-vivo without adversely affecting energy metabolism. The active compounds have the general formula Image (I) or in-vivo hydrolysable functional derivatives of the carboxylic groups thereof, wherein R1 and R2 each independently represents an unsubstituted or substituted hydrocarbyl or heterocyclyl radical; X and Y each independently represents hydrogen, optionally substituted lower alkyl, halogen, cyano, carboxy, lower alkoxycarbonyl or carbamoyl; and Q represents a diradical consisting of a linear chain of 8 to 14 carbon atoms, one or more of which may be replaced by heteroatoms, said chain being optionally substituted by inert substituents and one or more of said carbon or heteroatom chain members optionally forming part of a ring structure. The invention also provides pharmaceutical compositions comprising the aforementioned compounds of formula (I) for the treatment of obesity, hyperlipidemia and maturity-onset diabetes.
416713
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Syndromex Ltd.
LandOfFree
Long-chain .alpha., .omega.-dicarboxylic acids and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Long-chain .alpha., .omega.-dicarboxylic acids and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Long-chain .alpha., .omega.-dicarboxylic acids and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1236814