Regulating retroviral replication, infection, and pathogenesis

Details Regulating retroviral replication, infection, and pathogenesis Regulating retroviral replication, infection, and pathogenesis

A - Human Necessities

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A61K 31/70 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01)

Patent

CA 1306951

REGULATING RETROVIRAL REPLICATION, INFECTION, AND PATHOGENESIS Abstract Glucosidase I inhibitors as therapeutic agents for combatting nondefective retroviral pathogens, including the aetiological agents of AIDS and feline leukemia. Administration of a processing glucosidase I inhibitor, preferably castanospermine, interrupts the replication of the retrovirus in infected cells, alleviates pathogenic effects associated with the presentation of viral env glycoproteins on infected cells, and may furthermore prevent infection of target cells by interrupting expression of endogenous receptors recognized by the virion.

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