Sustained release semi-permeable capsule

A - Human Necessities – 61 – K

Patent

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Details

167/154, 167/4,

A61K 9/66 (2006.01) A01N 25/00 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01)

Patent

CA 1230054

ABSTRACT OF THE DISCLOSURE Disclosed are dispensing systems for releasing a substance at a substantially constant rate and methods for its manufacture. The composition comprises semi- permeable capsules containing the material to be released. The capsules comprise membranes having pores of dimensions sufficient to control the kinetics of release provided there is maintained a large intracapsular concentration of the substance relative to the concentration desired in the extracapsular environment. The compositions may be produced by forming permeable capsules, suspending the capsules in a solution containing a high concentration of the substance to load the intracapsular volume, and then post-treating the capsules to reduce the size of the pores.

451981

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