Method for the production of therapeutically administrable...

A - Human Necessities – 61 – K

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167/103.05

A61K 35/16 (2006.01) A61L 2/00 (2006.01) C07K 14/755 (2006.01) C07K 14/765 (2006.01) C07K 16/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1205012

ABSTRACT OF THE DISCLOSURE: There is disclosed a method for the production of thera- peutically administrable plasma derivatives filled in final containers, which are free of prekallikrein activa- tor, hypotensively active constituents and other undesired pharmacologically active substances, of plasma or plasma crude fractions by stepwise enrichment of the plasma pro- teins, sterile filtration and optionally virus inactiva- tion. In order to make available such plasma fractions that do not develop pharmacologically negative side ef- fects when applied and are producible with an improved activity and yield, C1-esterase inhibitor is added during the production process of the plasma derivative, yet prior to its filling into final containers.

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