Compounds, compositions and method of treatment for...

Details Compounds, compositions and method of treatment for... Compounds, compositions and method of treatment for...

A - Human Necessities

61

K

167/226

A61K 31/47 (2006.01)

Patent

CA 1220139

ABSTRACT The invention relates to a composition comprising a biologically acceptable carrier and an amount sufficient to cause the desired therapeutic effect of a protoberberine alkaloid or its biologically acceptable salt, which compound is effective to increase the contractility of the mammalian heart as shown by a positive inotropic effect, accompanied by at least one of the following symptoms: improved aortic blood flow, decrease in heart rate, decrease in systemic arterial pressure, reduction of afterload of the left ventricle, decrease in preload of the left ventricle, decrease in calculated vessel peripheral resistance, decrease in mean arterial pressure and freedom of arrhythmias.

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