Naphthalenyl- and quinolinyl-amino substituted phenols

Details Naphthalenyl- and quinolinyl-amino substituted phenols Naphthalenyl- and quinolinyl-amino substituted phenols

C - Chemistry, Metallurgy

07

C

167/179, 260/557

C07C 215/76 (2006.01) A61K 31/135 (2006.01) C07D 215/12 (2006.01) C07D 215/16 (2006.01) C07D 215/38 (2006.01)

Patent

CA 1285951

ABSTRACT p-Aminophenols are provided having the struc- ture Image wherein m is 0 to 5; X is CH or N; R1 and R2 may be the same or different and are H, lower alkyl, aryl, hydroxy, hydroxyalkyleneoxy, alkylthio, alkoxy, alk- anoyloxy, aryloxy, halo, carboxy, alkoxycarbonyl or amido; R3 is H, lower alkyl, alkanoyl or aroyl; and R4 is H, lower alkyl or alkanoyl, and including acid- addition salts thereof, with the proviso that when R4 is benzoyl, R2 is other than H. These compounds together with the compounds defined in the above proviso are useful as inhibi- tors of leukotriene production and as such are use- ful as antiallergy, anti-inflammatory and anti- psoriatic agents.

517428

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