Therapeutically active enzyme derived from hyaluronidase

Details Therapeutically active enzyme derived from hyaluronidase Therapeutically active enzyme derived from hyaluronidase

C - Chemistry, Metallurgy

12

N

195/125

C12N 9/26 (2006.01) A61K 38/43 (2006.01)

Patent

CA 1168610

ABSTRACT The invention relates to a therapeutically active enzyme which is an odorless, white powder, the pH of a 15,000 to 22,000 IU/ml. solution of which in carbon dioxide- free physiological saline solution suitable for injection is 4.5 to 7.5, the solution being clear and colorless; a solution of 50,000 IU of which in 3 ml. carbon dioxide- free physiological saline solution suitable for injection has a light absorption of not more than 0.60 at 280 nm. and of not more than 0.37 at 260 nm.; the enzyme having the following percentage amino acid analyzis: Image The enzyme further has a total hexose content of 10.6 ? 0.003%, contains not more than 5 µg. albumin per 220,000 KU of activity and has a molecular weight of 62,000 to 70,000 determined by gel infiltration and a specific activity of at least 30,000 IU/mg. The enzyme of the invention is useful as an aid to the survival of myocardial tissue after infarction and is also useful for the treatment of peripheral vascular disease.

391668

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