Process for the preparation of heterocyclic substituted...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/04 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1280754

ABSTRACT This invention provides new heterocyclic oxazolones of the formula: Image wherein Y is an oxygen or sulfur group; R1 is a hydrogen or a (C1-C5) alkyl group when R2 is R; R2 is a hydrogen or a (C1-C5) alkyl group when Rl is R; and R is a 2-, 3- or 4-pyridyl group optionally substituted with a hydroxy, halogen, (C1- C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkyl- thio, (C1-C5) alkylsulfinyl, (C1-C5) alk- ylsulfonylr cyano, carboxy, carb(C1-C5)al- koxy, carbamido, (C1-C5) alkanoylamino, imidazolyl group, or R is a 2- or 3- furanyl, 2- or 3-thienyl or 2- or 3-pyranyl group; which enhance myocardial contractile force and cardiac function and are therefore useful as cardiotonics in the treatment of heart failure.

522445

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