C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 260/304
C07D 413/04 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01)
Patent
CA 1280754
ABSTRACT This invention provides new heterocyclic oxazolones of the formula: Image wherein Y is an oxygen or sulfur group; R1 is a hydrogen or a (C1-C5) alkyl group when R2 is R; R2 is a hydrogen or a (C1-C5) alkyl group when Rl is R; and R is a 2-, 3- or 4-pyridyl group optionally substituted with a hydroxy, halogen, (C1- C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkyl- thio, (C1-C5) alkylsulfinyl, (C1-C5) alk- ylsulfonylr cyano, carboxy, carb(C1-C5)al- koxy, carbamido, (C1-C5) alkanoylamino, imidazolyl group, or R is a 2- or 3- furanyl, 2- or 3-thienyl or 2- or 3-pyranyl group; which enhance myocardial contractile force and cardiac function and are therefore useful as cardiotonics in the treatment of heart failure.
522445
Claxton George P.
Jones Winton D. Jr.
Schnettler Richard A.
Merrell Dow Pharmaceuticals (canada) Inc.
Osler Hoskin & Harcourt Llp
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