Carbapenem process

Details Carbapenem process Carbapenem process

C - Chemistry, Metallurgy

07

D

260/242, 260/299

C07D 487/04 (2006.01) C07D 477/20 (2006.01) C07F 9/58 (2006.01)

Patent

CA 1273014

ABSTRACT Disclosed is a new and more efficient process for producing carbapenem antibiotic derivatives having a 2- substituent of the general formula Image in which A represents a C1-C6 straight or branched chain alkylene group; R5 represents an optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aryl, araliphatic, heteroaryl, heteroaraliphatic, heterocyclyl or heterocyclyl-aliphatic radical; and Image represents a nitrogen-containing aromatic heterocycle attached to the alkylene group A at a ring carbon atom and quaternized by substituent R5.

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