Dihydropyridines

Details Dihydropyridines Dihydropyridines

C - Chemistry, Metallurgy

07

D

260/251, 260/249

C07D 401/00 (2006.01) C07C 45/00 (2006.01) C07C 47/55 (2006.01) C07D 211/90 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 473/00 (2006.01)

Patent

CA 1215050

Abstract Title: Dihydropyridines Dihydropyridines of the formula:- Image (I) and their pharmaceutically acceptable acid addition salts; wherein R is an optionally substituted aryl or heteroaryl group; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; Y is -(CH2)n- where n is 2, 3 or 4 and is optionally substituted by 1 or 2 methyl groups; and R3 is an optionally substituted 5- or 6-membered heterocyclic group attached to the adjacent nitrogen atom by a carbon atom, said heterocyclic group being optionally fused to a further 5- or 6-membered heterocyclic group or to a benzene ring, said further heterocyclic group and benzene ring also being optionally substituted. The compounds are calcium antagonists useful as anti-ischaemic and antihypertensive agents. PLC 366

443770

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