A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/164, 167/229
A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/24 (2006.01) A61K 9/32 (2006.01) A61K 9/58 (2006.01) A61K 31/44 (2006.01) A61K 31/455 (2006.01)
Patent
CA 1200494
ABSTRACT OF THE DISCLOSURE A spherical pellet like composition of nicardipine showing long acting activity is produced by dissolving (a) nicardipine or a salt thereof (b) a pH-dependent additive and/or a water-soluble polymer, and, if necessary, a surface active agent in an organic solvent, a mixture of organic solvents or a mixture of water and an organic solvent and spray-coating small granular nuclei such as, for example, sugar particle with the solution. The spherical pellet like composition of nicardipine may be further spray-coated with an organic solution of a medicament permeating material for further prolonging the long acting activity. Moreover, the spherical pellet like composition may be mixed with the spherical pellet like composition coated with the medicament permeating material.
418228
Aruga Masayoshi
Kawata Hiroitsu
Kubota Yukio
Ohmura Tadayoshi
Sonobe Takashi
Johnson Douglas S. Q.c.
Yamanouchi Pharmaceutical Co. Ltd.
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