Process for obtaining laxative compounds from senna drug

Details Process for obtaining laxative compounds from senna drug Process for obtaining laxative compounds from senna drug

C - Chemistry, Metallurgy

07

H

260/233.4

C07H 15/244 (2006.01) A01M 7/00 (2006.01)

Patent

CA 1203800

ABSTRACT The present invention provides a process for obtaining laxative compounds from senna drug, wherein a) the senna drug is extracted with aqueous methanol by countercurrent percolation and the extract con- centrated at a temperature of ? 50°C. until the methanol has been completely removed from the extract; b) the extract obtained is purified by continuous liquid-liquid extraction with an organic solvent; c) the refined material (raffinate) obtained is trans- ferred to a crystallisation apparatus, acidified, while stirring, to a pH of 1.5 to 2.0, seeded with sennoside crystals, left to crystallise while stirring and the crystalline crude sennoside obtained separated off; d) whereafter, the crude sennosides are, if desired, recrystallised and optionally e) 10 parts by weight of the mother liquor from c) mixed, while stirring, with 2 parts by weight of sodium chloride and the semi-solid mass coagulated on the surface is decanted off, washed and option- ally extracted with 95% methanol and the methanol fraction concentrated and the residue dried.

414539

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