Tetrahydronaphthoxazoles

Details Tetrahydronaphthoxazoles Tetrahydronaphthoxazoles

C - Chemistry, Metallurgy

07

D

260/309, 260/314

C07D 235/02 (2006.01) C07C 43/215 (2006.01) C07C 205/25 (2006.01) C07D 263/52 (2006.01) C07D 263/60 (2006.01) C07D 265/34 (2006.01) C07D 277/60 (2006.01) C07D 413/04 (2006.01)

Patent

CA 1188304

ABSTRACT OF THE DISCLOSURE Compounds having the structures: Image I wherein n is 3,4 or 5, X is 0, S, or N, R1 is H or alkyl, R2 is H, alkyl, hydroxyl, alkoxy, cyano, phenyl, carboxyl, tetrazole or halogen, R3 is CN, tetrazole, carboxamide or Image wherein Z is 0, S, or NH, R4 is H, alkyl, alkoxyalkyl, aryl, or aralkyl, and wherein the portion of the compound containing n may be carbocyclic or contain a hetero atom, or may be an aryl or heteroaryl ring. The compounds are useful as antiallergic agents, and are formulated with a pharmaceutical carrier for oral, parental, inhalational, or rectal means of administration.

407337

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