Bioerodable implant composition

Details Bioerodable implant composition Bioerodable implant composition

A - Human Necessities

61

K

167/166, 167/325

A61K 9/58 (2006.01) A61L 24/00 (2006.01) C08K 3/24 (2006.01) C08K 3/32 (2006.01) A61F 2/02 (2006.01) A61F 2/46 (2006.01)

Patent

CA 1324082

ABSTRACT OF THE DISCLOSURE An improved bone cement is comprised of a particulate biocompatible calcium phosphate ceramic and particulate resorbable calcium salt dispersed in a cross-linked biodegradable polyester matrix. The polymer/salt-particle composite exhibits good biomechanical strength/modules characteristics with surgically acceptable cure times. When used for sustained release of biologically active agents in a physiological environment, controlled release of biological agents that are mixed into the composite can be achieved as the cement biodegrades. When used for bone/implant fixation, or as a filler or cement for bone repair, gradual biodegradation of the cement composite permits, under suitable circumstances, eventual replacement of the cement with developing bone tissue.

561225

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