Hydroquinone derivatives and production thereof

Details Hydroquinone derivatives and production thereof Hydroquinone derivatives and production thereof

A - Human Necessities

61

K

167/248, 260/465

A61K 31/215 (2006.01) A61K 31/185 (2006.01)

Patent

CA 1240694

Abstract of the disclosure A compound of the formula: Image (I) [wherein either one of R1 and R2 stands for hydrogen atom or SO3H and the other one does SO3H, Z stands for Image , Image or Image (where m denotes an integer of 1-22, n denotes an integer of 0-21, R3 stands for hydrogen atom or an acyl group having 2 to 4 carbon atoms, and R4 does hydrogen atom or an alkyl group having 1 to 4 carbon atoms)] and pharmacologically acceptable salts thereof is novel and has various pharmacological actions such as antioxidative action, inhibitory action of SRS-A generation, immunoregulatory action, action on lysosome-membrane, cell-activating action, phosphodiesterase- inhibitory action, etc. The compound of formula (I) is prepared by sulfating a corresponding hydroquinone or by introducing the OSO3H group into a compound of the formula: Image wherein either one of R5 and R6 is hydrogen and the other is hydroxyl, with a peroxodisulfate.

453231

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