A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
195/46
A61K 38/19 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/535 (2006.01) C12N 15/27 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1341142
Macrophages and precursor monocytes are activated to exhibit tumoricidal activity by stimulation solely with granulocyte-macrophage colony stimulating factor. A patient suffering from tumors can be treated by direct administration of therapeutically effective quantities of activated granulocyte-macrophage colony stimulating factor. Homogeneous granulocyte-macrophage colony stimulating factor for use in activating macrophages and monocyte precursors is prepared by recombinant DNA techniques. The gene coding for granulocyte-macrophage colony stimulating factor is isolated and then recombinant protein product expressed in an appropriate expression system. The granulocyte-macrophage colony stimulating factor recovered from the expression system is purified to homogeneity by reverse phase high-performance liquid chromatography.
516034
Anderson Dirk M.
Cantrell Michael A.
Cerretti Douglas P.
Conlon Paul J. III
Cosman David J.
Alcafleu Management Gmbh & Co. Kg
Immunex Corporation
Smart & Biggar
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