Substituted 1-pyridyloxy-3-indolylalkylamino-2- propanols,...

Details Substituted 1-pyridyloxy-3-indolylalkylamino-2- propanols,... Substituted 1-pyridyloxy-3-indolylalkylamino-2- propanols,...

C - Chemistry, Metallurgy

07

D

167/228, 167/229

C07D 401/12 (2006.01) C07D 209/14 (2006.01)

Patent

CA 1236834

Abstract of the Disclosure 1-(Pyridinyloxy)-3-(indolylalkylamino)-2-propanols, novel cardiovascular agents having vasodilator activity and a range of adrenergic beta-receptor blocking action, are prepared by any one of three routes that comprise a novel general process. The general process comprises coupling a hydroxyl- or halogen- substituted pyridine with a suitable halogen- or hydroxyl- substituted propanol or incipient propanol intermediate; and the products of these couplings are also novel. In the preferred of the three coupling routes, product 1-(pyridinyloxy)-3- (indolylalkylamino)-2-propanols are formed directly; in the other two coupling routes further processing of the coupling products is required to form the 1-(pyridinyloxy)-3-(indolyl- alkylamino)-2-propanols. Preferred compounds bear an amide or cyano substituent in the 3- position of the pyridine ring.

435880

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