System for the controlled-rate release of active substances

Details System for the controlled-rate release of active substances System for the controlled-rate release of active substances

A - Human Necessities

01

N

167/164, 167/321

A01N 25/34 (2006.01) A01N 25/10 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01)

Patent

CA 1298479

ABSTRACT A system for the controlled-rate release of active substances, consisting of a) a deposit-core comprising the active substance and having defined geometric form; b) a support-platform applied to said deposit-core. Said deposit-core contains, mixed with the active substance, a polymeric material having a high degree of swelling on contact with water or aqueous liquids, a gellable polymeric material, said polymeric materials being replaceable by a single polymeric material having both swelling and gelling properties, and other adjuvants able to provide the mixture with suitable characteris- tics for its compression and for its intake of water. Said support-platform consists of a polymeric material insoluble in aqueous liquids and partially coating said deposit-core. The intensity and duration of the swelling force of said polymeric material with a high degree of swelling constitutes the primary factor in controlling the release of the active substance.

525469

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