Cephalosporine compounds with antibiotic activity

Details Cephalosporine compounds with antibiotic activity Cephalosporine compounds with antibiotic activity

C - Chemistry, Metallurgy

07

D

260/107

C07D 501/20 (2006.01) C07D 499/00 (2006.01)

Patent

CA 1173435

NEW CEPHALOSPORINE COMPOUNDS WITH ANTIBIOTIC ACTIVITY ABSTRACT OF THE DISCLOSURE New derivatives of 1,3-thiazolidin-4-yl carboxylic acid of the general formula I Image (I) wherein: R represents hydrogen or acyl; R' represents hydrogen, a pharmaceutically acceptable inor- ganic or organic cation, (C1-4)alkyl, 2,2,2-trichloroethyl, acetonyl, benzyl, benzyl substituted by nitro or methoxy, phenyl, nitrophenyl, benzhydryl or trimethylsilyl; R' may also represent a radical capable of providing meta- bolic activation in vivo selected from acetoxymethyl, piva- loyloxymethyl, phthalidyl, benzoyloxymethyl, 5-indanyl, a group of formula Image or a group of formula -CH2NH-?-R" in which R" stands for (C1-4)alkyl, (C5-6) cycloalkyl or aryl; A represents hydrogen, pyridinium, lower alkanoyloxy or heterocyclicthio. The compounds possess antibacterial utility against microbial infections in man, animals and plants.

381453

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