Carbapenem antibiotics

Details Carbapenem antibiotics Carbapenem antibiotics

C - Chemistry, Metallurgy

07

D

260/242, 260/299

C07D 487/04 (2006.01) C07D 213/32 (2006.01) C07D 233/54 (2006.01) C07D 249/04 (2006.01) C07D 249/08 (2006.01) C07D 257/04 (2006.01) C07D 277/26 (2006.01) C07D 285/06 (2006.01) C07D 477/20 (2006.01) C07F 7/18 (2006.01) C07F 9/58 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 1269978

ABSTRACT Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula Image in which A represents a C1-C6 straight or branched chain alkylene group; R5 represents an optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aryl, araliphatic, heteroaryl, heteroaraliphatic, heterocyclyl or heterocyclyl-aliphatic radical and Image represents a nitrogen-containing aromatic heterocycle attached to the alkylene group A at a ring carbon atom and quaternized by substituent R5. Such derivatives are useful as potent antibacterial agents.

436924

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