C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/466.1, 260/2
C07C 35/44 (2006.01) C07C 69/96 (2006.01) C07C 229/08 (2006.01) C07C 271/22 (2006.01) C07D 211/40 (2006.01) C07D 211/46 (2006.01) C07D 295/15 (2006.01) C07D 303/14 (2006.01) C07D 317/72 (2006.01) C07D 493/08 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1243025
ABSTRACT Aphidicolane derivatives of the formula: Image wherein R1 stands for hydrogen or a hydroxy radical, R2 stands for a hydroxy radical, R3 stands for a formyl or hydroxymethyl radical, or for the group -CH20.CO.OR6, wherein R6 stands for a phenyl or phenylalkyl radical, or R2 and R3 are joined together to form the group -O.CO.OCH2-; R4 stands for a hydroxy radical; R5 stands for a formyl radical, a hydroxyalkyl radical -(CH2)1-3OH, a radical -CHR7OH, wherein R7 stands for a defined radical, or R5 stands for an alkyl, or phenyl radical, or for the group -CH2O.CO.OR8, wherein R8 stands for a phenyl or phenylalkyl radical, or R5 stands for the group -CH20.CO.(CH2)m-NR R wherein m, R9 and R10 have defined values, or R5 stands for the group -CH2O.SO2.R13, wherein R13 stands for a defined radical; or R4 and R5 are joined together to form the group -O.CH2- or -O.CO.OCH2-; ii and, where appropriate, pharmaceutically-acceptable salts thereof. Processes for the preparation of said aphidicolane derivatives. Pharmaceutical compositions comprising one of the compounds and a pharmaceutical diluent or carrier. The compounds exhib it inhibitory activity against DNA-containing viruses and they inhibit the growth of some tumours.
432812
Smart & Biggar
Zeneca Limited
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