Method of inactivating reproductive filterable pathogens

A - Human Necessities – 61 – K

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A61K 35/16 (2006.01) A61L 2/00 (2006.01)

Patent

CA 1245154

ABSTRACT OF THE DISCLOSURE: There is disclosed a method of inactivating reproductive filterable pathogens in tissue adhesives containing fibri- nogen and Factor XIII, with their biologic activity being largely preserved. In order to provide a tissue adhesive preparation of human or animal origin, which exhibits a high safety with respect to reproductive filterable patho- gens and whose biologic activity is largely preserved, preparations having a minimum content of 100 units of Factor XIII/g of fibrinogen are heated in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.

490555

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