C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/295, 260/599
C07D 295/12 (2006.01) C07D 213/36 (2006.01) C07D 213/38 (2006.01) C07D 223/16 (2006.01) C07D 295/13 (2006.01) C07D 307/33 (2006.01)
Patent
CA 1191846
ABSTRACT There are described compounds of formula I, Image I in which D1 represents a group of formula II, Image II where R1 and R5, or R3 and R5 may form a chain -CH2CH2-, or R4 and R5 may form a chain -CH2-, or R3, R4 and R5 are each hydrogen, the remainder of R1, R3 and R4, which may be the same or different, being hydrogen, alkyl or phenyl, none, one or two of R6, R7, R8 and R9 represent hydroxy and the remainder represent hydrogen, X represents a chain -(CH2)n-, optionally substituted by hydroxy, n is an integer from 1 to 7 inclusive, D2 represents hydrogen, alkyl, phenyl; alkyl substituted by one or more of hydroxy, pyridyl, phenyl; or alkyl substituted by phenyl which in turn is substituted - 2 - by halogen, alkyl, amino, alkoxy or nitro, or D2 represents a group of formula III, Image III where R2 and R12, or R10 and R12 may form a chain -CH2-CH2-, or R11 and R12 may form a chain -CH2-, or R10, R11 and R12 are each hydrogen, the remainder of R2, R10 and R11, which may be the same or different being hydrogen, alkyl or phenyl, none, one or two of R13, R14, R15 and R16 represent hydroxy, and the remainder represent hydrogen, which they are attached, form a 5 or 6 membered heterocyclic ring, provided that when X is not substituted by hydroxy and i) when R3, R4 and R5 are hydrogen, R1 and R2 are both hydrogen or lower alkyl, and two of R6, R7, R8 and R9 are hydroxy, D2 is not identical or D1, or ii) when R1, R3, R4, R5, R6, R7, R8 and R9 are hydrogen, R2 and D2 do not each represent lower alkyl, or do not together with the nitrogen atom to - 2 - - 3 - which they are attached, form a 5 or 6 membered heterocyclic ring, or III) when R1, R4, R5, R6, R7, R8 and R9 are hydrogen, and R3 is alkyl, D2 is not identical to D1, or iv) when R1 is phenyl, R3 and R5 together form the chain -CH2CH2-, R6, R7, R8 and R9 are hydrogen, n is 1, D2 and R2 do not each represent hydrogen or alkyl, or do not together form a heterocyclic ring, and pharmaceutically acceptable derivatives thereof. There are also described methods form making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds. - 3 -
408660
Brown Rodney A.
Dixon John
Farmer John B.
Ince Francis
Fisons Plc
Ridout & Maybee Llp
LandOfFree
Derivatives of .alpha.,.omega.-alkylene-diamines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of .alpha.,.omega.-alkylene-diamines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of .alpha.,.omega.-alkylene-diamines will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1260222