Pharmacologically active peptides

Details Pharmacologically active peptides Pharmacologically active peptides

C - Chemistry, Metallurgy

07

K

530/5.1

C07K 14/70 (2006.01)

Patent

CA 1187872

Abstract of the Disclosure Compounds of the formula Image and pharmaceutically acceptable non-toxic acid addition salts thereof, in which R is hydrogen, methyl, or ethyl; A is the residue of a D-amino acid selected from Ala, Abu, Nva, Val, Nle, Leu, Ile, Gly(Al), Gly(Cp), Met, Cys(Me), Met(O), Cys(Me)(O), Ser, Thr, and Hse; R1 is hydrogen, C1-C3 primary alkyl, cyclo- propylmethyl, allyl, or propargyl; X is bromo, iodo, chloro, C1-C3 alkyl, tri- fluoromethyl, or C1-C2 alkoxy; B is the residue of a D- or L-amino acid lacking its carboxyl moiety and selected from Gly, Ala, Abu, Nva, Val, Nle, Leu, Ile, Pgl, Cys(Me), Cys(Me)(O), Cys(Me)(02), Cys(Et), Cys(Et)(O), Cys(Et)(O2), Met, Met(O), Met(02), Eth, Eth(O), Eth(02), Ser(Me), Ser(Et), Hse(Me), and Hse(Et) as well as any of such residues substituted at the amino nitrogen by a C1-C3 primary alkyl; Z is -CH20R2, Image , or Image , in which R2 is hydrogen or C1-C3 alkyl; subject to the proviso that, when R1 is other than hydrogen, B is the residue of an amino acid that lacks substitution at the amino nitrogen; which are useful analgesic agents, are described.

388253

Affiliated with

Also associated with

Rating

Pharmacologically active peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmacologically active peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmacologically active peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1260454